Frailty is the manifestation of health deficits accumulated over a lifetime, as modulated by individual environmental, genetic, and lifestyle factors. Frailty, comorbidity, and functional status have all been shown to be predictive for mortality and adverse health outcomes. The Multidimensional Prognostic Index (MPI), Charlson Comorbidity Index (CCI), and Barthel Index (BI) have been developed to quantify frailty, comorbidity, and functional status, respectively.
The work described on this page was carried out by 2 medical students over a period of 3 years (2015-2018) during medical school, under local supervision. This page is not a detailed account of research outcomes.
We utilised the MPI, CCI, and BI to characterise frailty amongst endÂ-stage renal disease patients, with a primary focus on the MPI. We investigated the distribution of participants amongst the three MPI risk severity groups (MPI 1-3), evaluated the correlation between the MPI, CCI, and BI, and correlated this data with longitudinal outcomes including mortality, ED presentations, hospitalisations, and length of stay.
A literature review regarding the development, validation, and use of the Multidimensional Prognostic Index (MPI), Charlson Comorbidity Index (CCI), and Barthel Index (BI) was completed. The review also investigated work on inter-scale correlations, and any published characteristics of the interest population.
93 patients were consented and clinically interviewed by two medical students. Each interview covered an inventory of approximately 100 items and took about 45-60 minutes to complete. Longitudinal outcome data was collected at 6- and 12-months by accessing the local electronic record.
